Identification of lysosomal genes associated with prognosis in lung adenocarcinoma
نویسندگان
چکیده
Background: Lung adenocarcinoma (LUAD) is the most common subtype of lung cancer, representing 40% all cases this tumor. Despite immense improvements in understanding molecular basis, diagnosis, and treatment LUAD, its recurrence rate still high.
منابع مشابه
SIRT1 expression is associated with poor prognosis of lung adenocarcinoma
Several studies have reported that the overexpression of Sirtuin 1 (SIRT1) was associated with poor prognosis in various human cancers. However, little is known regarding the prognostic value of SIRT1 in lung adenocarcinoma. Therefore, the aim of this study is to evaluate the role of SIRT1 in the prognosis of lung adenocarcinoma patients. Using a tissue microarray, we detected SIRT1 expression ...
متن کاملPIK3CA gene mutation associated with poor prognosis of lung adenocarcinoma
PURPOSE PIK3CA gene mutations have been detected in many malignancies, but the frequency of different mutations and their role in the carcinogenesis of lung adenocarcinoma are still unclear. The purpose of this study was to explore the clinical pathological impact and prognostic implications of PIK3CA mutations in lung adenocarcinoma. METHODS Five common PIK3CA mutations (E542K, E545K, and E5...
متن کاملProliferation genes in lung development associated with the prognosis of lung adenocarcinoma but not squamous cell carcinoma
There are many similarities between embryonic development and tumorigenesis, and gene expression profiles show that certain correlations exist between the gene signature during development and the clinical phenotypes of different cancers. Our group previously reported the gene expression profiles of human lung development, and the expression of one group of proliferation-related genes (PTN1 gen...
متن کاملGene Regulation Network Based Analysis Associated with TGF-beta Stimulation in Lung Adenocarcinoma Cells
Background: Transforming growth factor (TGF)-β is over-expressed in a wide variety of cancers such as lung adenocarcinoma. TGF-β plays a major role in cancer progression through regulating cancer cell proliferation and remodeling of the tumor micro-environment. However, it is still a great challenge to explain the phenotypic effects caused by TGF-β stimulation and the effect of TGF-β stimulatio...
متن کاملIdentification of urine biomarkers associated with lung adenocarcinoma
Lung adenocarcinoma (LAC) progression is accompanied by changes in protein levels that may be reflected in body fluids, such as urine. Urine collected from LAC patients (n=34) and healthy controls (n=36) was analyzed via matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) combined with weak cationic exchange magnetic beads. The results revealed 76 urinary...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Translational lung cancer research
سال: 2023
ISSN: ['2226-4477', '2218-6751']
DOI: https://doi.org/10.21037/tlcr-23-14